Endocrine Abstracts

A 40-year-old female presented with lethargy, poor mobility and blurred vision for 2 weeks and 6 months of amenorrhoea. On examination she was markedly Cushingoid with proximal myopathy and normal visual fields. She was hypertensive, with peripheral oedema and leg ulcers. Bloods revealed leucocytosis, hyperglycemia, and ketonuria. She was commenced on insulin. CXR was clear.Endocrine review diagnosed Cushings syndrome. Cortisol did not suppress overnight...

Maturity Onset Diabetes of the Young (MODY) accounts for upto 2% of all patients with diabetes. Hepatocyte Nuclear Factor 1 alpha (HNF1-A) MODY is the most common subtype accounting for 30–70% of all MODY cases. Typically, it presents in young adults below the age of 45, frequently < 25 with autosomal dominant family history of diabetes, absence of autoimmune markers and insulin resistance and c-peptide positivity.DKA is a rare complication of M...

A 54 years old female with no significant past medical history was referred by her GP with thyrotoxic symptoms which were not improving on Carbimazole 40 mg daily over the last 3 months in spite of good compliance with the drug. Her initial FT4 was 49.0 pmol/l with TSH suppressed to <0.01 and she was started on Carbimazole 20 mg which a month later was increased to 40 mg/day when there was no improvement in her TFTs. Her TFTs at this point showed FT4 ...